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EP4 levels are reduced and uPA induction is inhibited in response to ERG knockdown. (A) EP4 protein levels were evaluated by immunoblot assays. Result shows that EP4 is downregulated in response to ERG knockdown. (B) expression of upa was assessed by immunoblotting at 1, 2, 4, 8 and 12 hours time points in VCaP cells treated with PGE2 as described in the Methods and Materials. PGE2 induces uPA in NT siRNA treated cells, whereas, ERG knockdown prevents uPA induction.
