Table 1.
Clinical presentation of GnRH-deficient women
| Full cohort (n = 248) | KS women (n = 116) | nIHH women (n = 132) | P value | |
|---|---|---|---|---|
| Age, yr | 28.5 ± 0.9 | 27.2 ± 1.3 | 29.8 ± 1.3 | 0.16 |
| BMI, kg/m2 | 25.4 ± 2 | 26.5 ± 2.6 | 23.1 ± 2.4 | 0.43 |
| Thelarche, % | 51% (44/86) | 50% (20/40) | 52% (24/46) | 1 |
| Menarche, % | 10% (10/98) | 8% (4/48) | 12% (6/50) | 0.7 |
| Pubarche, % | 88% (49/56) | 84% (21/25) | 90% (28/31) | 0.7 |
| Ovarian volume, cc | 2.8 ± 0.3 (n = 39) | 2.0 ± 0.4 (n = 18) | 3.4 ± 0.4 (n = 21) | 0.02 |
| LH, IU/liter | 0.6 ± 0.1 (n = 85) | 0.5 ± 0.1 (n = 44) | 0.7 ± 0.2 (n = 41) | 0.13 |
| FSH, IU/liter | 1.5 ± 0.2 (n = 85) | 1.2 ± 0.3 (n = 44) | 1.7 ± 0.2 (n = 41) | 0.12 |
| Baseline study | ||||
| Apulsatile, % | 73% (51/70) | 70% (24/34) | 75% (27/36) | 0.8a |
| Pulsatile, % | 27% (19/70) | 30% (10/34) | 25% (9/36) | |
| Low frequency and/or amplitude, % | 19% (13/70) | 21% (7/34) | 17% (6/36) | |
| Normal frequency and amplitude, % | 8% (6/70) | 9% (3/34) | 8% (3/36) |
a
Represents pulsatile vs. apulsatile patterns in KS vs. nIHH.