Table V.
Interaction between Runx, MAPK1, eIF4E and other genes in candidate pathway
| Gene | SNP | HRG | Pathway gene | SNP | HRG | Combined risk |
|
| OR (95% CI) | Interaction P value | ||||||
| Colon cancer | |||||||
| RUNX1 | rs2300395 | CC | BMPR1B | rs17616243 | CT/TT | 1.33 (1.08, 1.64) | 0.024 |
| BMPR1A | rs7088641 | TT | 1.25 (1.03, 1.52) | 0.042 | |||
| rs7279123 | CT/TT | TGFBR1 | rs10733710 | AA | 1.77 (1.09, 2.89) | 0.0359 | |
| rs2248720 | AA | Smad7 | rs4464148 | TC/CC | 1.38 (1.12, 1.71) | 0.019 | |
| RUNX2 | rs10948238 | TT | TGFBR1 | rs1571590 | GG | 3.37 (1.48, 7.71) | 0.0272 |
| Smad3 | rs16950687 | GG | 1.82 (1.06, 3.13) | 0.013 | |||
| Smad7 | rs12953717 | TT | 2.18 (1.47, 3.24) | 0.0056 | |||
| RUNX3 | rs6672420 | AA | NFκB1 | rs230510 | TT | 1.50 (1.12, 2.01) | 0.0239 |
| TGFB1 | rs4803455 | AA | 1.82 (1.38, 2.42) | 0.0476 | |||
| MAPK1 | rs8136867 | GG | BMP4 | rs17563 | TT | 1.57 (1.13, 2.19) | 0.023 |
| rs2298432 | CC | NFkB1 | rs13117745 | CC/CT | 3.58 (1.56, 8.19) | 0.0061 | |
| TGFBR1 | rs6478974 | TT | 1.39 (1.11, 1.74) | 0.0168 | |||
| Rectal cancer | |||||||
| RUNX1 | rs1981392 | CC | BMPR1A | rs7088641 | CC | 2.94 (1.11, 7.73) | 0.0171 |
| rs1474479 | AA | TGFB1 | rs1800469 | AA | 2.76 (1.11, 6.82) | 0.0373 | |
| rs11702779 | GG/GA | Smad3 | rs12708492 | CT/TT | 2.75 (1.49, 5.08) | 0.0108 | |
| rs8134380 | TT | rs16950687 | GG | 5.05 (1.67, 15.26) | 0.0084 | ||
| rs17293443 | CC | 15.17 (1.95, 117.96) | 0.0086 | ||||
| RUNX2 | rs2819863 | GC/CC | Smad4 | rs10502913 | AA | 3.30 (1.02, 10.60) | 0.0496 |
| rs7750470 | CC | Smad3 | rs7163381 | AA | 12.01 (1.51, 95.46) | 0.0119 | |
| NFKB1 | rs230510 | AA | 3.99 (1.67, 9.53) | 0.0216 | |||
| RUNX3 | rs6672420 | TT | BMPR1B | rs13134042 | GA/AA | 1.75 (1.26, 2.44) | 0.046 |
| rs2135756 | GG | NFKB1 | rs4648110 | AA | 2.97 (1.04, 8.50) | 0.0375 | |
HRG, high-risk genotype group.