Table 3.
Effects of various treatments on the lipid peroxidation and the anti-oxidants status of hyperlipidemic rat livers.
| Groups (n=6) | MDA (nmol/mg protein) | SOD (U/min/mg protein) | Catalase (U/min/mg protein) | GSH × 10-3 (μg/mg protein) |
|---|---|---|---|---|
| Group 1 | 1.85 ± 0.18 | 6.13 ± 0.67 | 167.20 ±14.00 | 933.00 ± 60.80 |
| Group 2 | 45.70 ± 18.40* | 13.98 ± 0.87* | 3.60 ± 0.10* | 357.60 ± 12.46* |
| Group 3 | 3.62 ± 0.08** | 15.15 ± 0.46 | 4.50 ± 0.63 | 458.40 ± 8.21 |
| Group 4 | 30.8 ± 4.30** | 4.77 ± 0.22**‡ | 221.00 ± 18.00**‡ | 398.70 ± 27.10 |
| Group 5 | 7.80 ± 0.79** | 4.58 ± 0.25**‡ | 162.00 ± 12.00**‡ | 363.00 ± 16.80 |
| Group 6 | 1.51 ± 0.20** | 5.98 ± 0.59**‡ | 45.50 ± 5.82*‡* | 718.20 ± 19.20** |
| Group 7 | 1.12 ± 0.06** | 4.20 ± 0.21**‡ | 277.12 ± 21.14** | 812.04 ± 22.48**‡ |
| Group 8 | 1.21 ± 0.07** | 6.48 ± 0.53**‡ | 147.40 ± 14.50**‡ | 1049.12 ± 59.77**‡ |
| Group 9 | 1.47 ± 0.14** | 7.57 ± 0.48**‡ | 116.90 ± 29.10**‡ | 1330.10 ± 82.20**‡ |
| Group 10 | 183.1 ± 12.20** | 25.87 ± 1.45 | 5.75 ± 0.49 | 480.60 ± 32.10 |
| Group 11 | 176 ± 3.20** | 23.41 ± 2.34 | 6.44 ± 0.63 | 640.00 ± 34.68** |
| Group 12 | 2.18 ± 0.51**‡ | 7.57 ± 0.47 | 49.70 ± 20.30** | 975.40 ± 23.60** |
| Group 13 | 176 ± 30.00 | 76.47 ± 3.02 | 8.80 ± 0.29 | 935.30 ± 36.12** |
| Group 14 | 125.5 ± 30.00**‡ | 147.50 ± 9.43 | 17.94 ± 1.73** | 365.30 ± 21.12 |
All values represent Mean ± SEM from six rats. Statistical analysis was carried out using One Way ANOVA followed by Tukey's test. The value of P < 0.05 was considered statistically significant.
*
compared with normal group
**
compared with hyperlipidemic control group
‡
compared with atorvastatin-niacin.