Table 2.

Effects of 7-epiclusianone (7-Epi), fluoride (F) and associations on caries development (smooth-surface and dentin severity) in rats, after a 5-week experiment.

	Smooth surface

		Severity

Treatments^*	Total	Ds	Dm	Dx
Vehicle control	76.2 (10.1)^a	42.5 (11.8)^a	18.3 (7.4)^a	6.4 (7.2)^a
7-Epi 250 µg ml⁻¹	62.9 (7.4)^b	25.5 (7.8)^b	3.3 (4.8)^b	1.9 (3.5)^b
7-Epi 250 µg ml⁻¹ + 125 ppm F	33.2 (2.6)^c	21.0 (7.7)^b	0.3 (0.5)^b	n.d.
Positive control (250 ppm F)	34.2 (4.5)^c	22.5 (6.5)^b	0.5 (0.8)^b	n.d.

Values denote means with SD in parentheses (n = 12) of Keyes’ scores modified by Larson. Values, for each parameter, followed by the same superscripts are not significantly different from each other (p > 0.05; ANOVA; comparison for all pairs using the Tukey–Kramer HSD).

Ds, dentin exposed; Dm, 3/4 of the dentin affected; Dx, whole dentin affected; n.d., non-detected.

Twice daily with 1-min exposure for each treatment.