Table 1.

Protein sets of Thermophilic and Mesophilic endoglucanases

	(α/β)8 fold			β-jelly roll fold			(α/α)6 fold
	GH5 and GH44 families			GH7 and GH12 families			GH8, GH48, and GH9 families
	Organism	PDB id	Length	Organism	PDB id	Length	Organism	PDB id	Length
	Pyrococcus horikoshii	2zum	458	Humicola insolens	1ojj	402	Clostridium thermocellum NCIB	1kwf	363
	Acidothermus cellulolyticus	1ece	358	Humicola grisea	1olr	224	Clostridium thermocellum	1clc	639
Thermophilic Endoglucanases	Clostridium cellulolyticum	1edg	380	Rhodotermus marinus	2bw8	227	Acyclobacillus acidocaldarius	3gzk	537
	Clostridium thermocellum	1cec	343	Fusarium oxysporum	3ovw	411	Clostridium thermocellum F7	1l1y	678
	Bacillus sp.kas-635	1g0c	364				Thermobifida fusca	1tf4	605
	Thermoascus auranticus	1h1n	305
	Uncultured bacterium	3ii1	535
	Clostridium thermocellum	2e4t	509
	Prevotella bryantii	3l55	353	Streptomyces lividans	2nlr	234	Gluconacebacter xylinus	1wzz	334
Mesophilic Endoglucanases	Bacillus agaradhaerens	7a3h	303	Hypocrea jecorina	1oa2	218	Nasutitermes takasagoensis	1ks8	433
	Erwinia chrysanthemi	1egz	291	Bacillus licheniformis	2jen	261	Clostridium cellulolyticum	1g87	614
	Clostridium acetobutylicum	3ik2	512	Aspergillus niger	1ks5	223	Clostridium cellulolyticum	1ia6	441
							Clostridium cellulolyticum	1g9g	629

A subset of proteins with less than or equal to 70% sequence identity was created as described in the Methods section. A protein is considered thermophilic if the source organism's optimum growth temperature is above 40°C. GH stands for glycosyl hydrolase.