Table 3.

Estimated Mean Change in Free and Cued Selective Reminding Score with Increasing Age, According to CETP V405 genotype group

	FCSRT		WAIS-R Digit Span		WAIS-R Digit Symbol
	B (95% CI)	P Value	B (95% CI)	P Value	B (95% CI)	P Value
Quadratic age trend	−0.02 (−0.03, −0.01)	<.0001	−0.005 (−0.009, −0.002)	0.002	−0.01 (−0.02, 0.001)	0.07
Linear age slope (per year) in reference group	−0.43 (−0.58, −0.29)	<.0001	0.05 (−0.01, 0.11)	0.10	−0.93 (−1.11, −0.75)	<.0001
Difference in Linear age slope between Valine Heterozygotes and Reference Group	0.07 (−0.09, 0.23)	0.39	0.01 (−0.05, 0.08)	0.67	0.06 (−0.11, 0.27)	0.42
Difference in Linear age slope between Valine Homozygotes and reference group	0.22 (0.02, 0.41)	0.03	−0.03 (−0.10, 0.06)	0.55	0.10 (−0.14, 0.36)	0.40

Abbreviations: CI, Confidence Interval; FCSRT, Free and Cued Selective Reminding Test; WAIS-R, Wechsler Adult Intelligence Scale-Revised.

Linear mixed effect model: Isoleucine homozygotes (I-I) were used as the reference group for each cognitive test. The model was centered at 85 and adjusted for sex, race, years of education, medical comorbidities, and presence of an APOE ε4 allele. The quadratic term evaluates for presence of accelerated non-linear decline. All parameter estimates are unstandardized regression coefficients. The regression coefficients for the difference in linear age slope estimates the change in cognitive score per additional year of age in each V405 genotype group compared to the reference group.