Table 1.

Risk of nicotine dependence based on haplotypes constructed from rs16969968 and rs588765

	Haplotype Risk of Nicotine Dependence
	High	Intermediate	Low
rs16969968	High-risk allele	Low-risk allele	Low-risk allele
rs588765	Low-expression allele	High-expression allele	Low-expression allele

Alleles of rs16969968 are represented as high-risk allele for nicotine dependence and low-risk allele for nicotine dependence. Alleles for rs588765 are represented as high expression of CHRNA5 and low expression of CHRNA5. The haplotype of high-risk allele (rs16969968) and high-expression allele (rs588765) is not listed because it is rare in the population.