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. 2011 Mar 2;6(3):e16839. doi: 10.1371/journal.pone.0016839

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Marsh et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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lys-7(ok1384)abl-1(ok171) double mutants remain hypersensitive to C. neoformans (A), similar to their corresponding single mutants; p<0.0001, [abl-1(ok171)lys-7(ok1384) n = 133; N2 n = 150], but the resistance exhibited by the single mutants to S. Typhimurium infection (B) has been completely suppressed; p>0.2, [abl-1(ok171)lys-7(ok1384) n = 110; N2 n = 94]. Double mutants between lys-7 and fat-5 or lys-7 and rga-6 were hypersensitive to C. neoformans infection (C), p<0.0001 in both cases, [N2 n = 207; lys-7(ok1384)fat-5(tm420) n = 100; lys-7(ok1384)rga-6(ok1316) n = 100]. Similarly, the resistance to S. Typhimurium exhibited by the lys-7 knockout strain was either unaltered (fat-5) or only slightly reduced (rga-6) by these secondary mutations (D), [N2 n = 170; lys-7(ok1384)fat-5(tm420) n = 100; lys-7(ok1384)rga-6(ok1316) n = 100].