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. 2011 Mar;137(3):299–314. doi: 10.1085/jgp.201010557

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© 2011 Pratt et al.

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Figure 4. — E128K mini-K_ATP channels have decreased intrinsic P_o. (A) Representative traces from inside-out voltage clamp recordings made from COSm6 cells transfected with Kir6.2ΔC36 (denoted as Kir6.2ΔC) alone or with WT, E128K, or F132L fTMD0 to form mini-K_ATP channels. Each trace is 10-s long (upper), with 1 s expanded (dashed box, lower) to illustrate bursting properties. The scale bar near the WT trace is 5 pA and applies to all traces. (B) Average intrinsic P_o of each channel type is given ±SEM. Distribution of individual data points and the number of patches analyzed are also shown. The average P_o of E128K mini-K_ATP channels is significantly different from WT mini-K_ATP channels and Kir6.2ΔC36 channels (*, P < 0.05; Student’s t test). (C) Average current of mini-K_ATP and Kir6.2ΔC36 channels in 1 mM ATP relative to maximal current in nucleotide-free Kint/EDTA solution. The number of inside-out patches tested is given; error bars represent SEM.