Figure 2.

C-terminal CNBD deletion affects hERG deactivation. (A–E) Channel schematics and two-electrode voltage-clamp recordings of a family of tail currents from hERG (A), hERG ΔN (B), hERG Δdistal C (C), hERG ΔCNBD/distal C (D), and hERG ΔCNBD (E). Currents were elicited using the pulse protocol indicated. (F) Plot of the time constants (τ) of deactivation derived from a single exponential fit (see Materials and methods) to the tail currents in A–E. The values are plotted as the means ± SEM. The error bars are within the points if not visible. n ≥ 5 for each.