Table 3.
Upregulation of autophagy/mitophagy related gene transcripts in Cav-1 (−/−) stromal cells
| Gene | Description | Fold change (KO/WT) | Accession number | p-value |
| Known Genes Associated with Autophagy | ||||
| 1200002N14Rik | RIKEN cDNA 1200002N14 gene | 1.24 | NM_027878 | 0.01 |
| Ambra1 | autophagy/beclin 1 regulator 1 | 1.93 | NM_172669 | 0.04 |
| Atg16l1 | autophagy-related 16-like 1 (yeast) | 1.33 | NM_029846 | 0.01 |
| Atg2a | ATG2 autophagy related 2 homolog A (S. cerevisiae) | 1.41 | NM_194348 | 0.02 |
| Atg2b | ATG2 autophagy related 2 homolog B (S. cerevisiae) | 1.82 | NM_029654 | 0.03 |
| Atg4a | autophagy-related 4A (yeast) | 1.33 | NM_174875 | 0.02 |
| Atg4d | autophagy-related 4D (yeast) | 1.57 | NM_153583 | 0.05 |
| Atg9a | autophagy-related 9A (yeast) | 1.73 | NM_001003917 | 0.005 |
| Becn1 | beclin 1, autophagy related | 1.28 | NM_019584 | 0.009 |
| Fam176a | family with sequence similarity 176, member A | 1.34 | NM_145570 | 0.02 |
| Foxo3 | forkhead box O3 | 2.25 | NM_019740 | 0.005 |
| Frap1 | FK506 binding protein 12-rapamycin associated protein 1 | 1.83 | NM_020009 | 0.04 |
| Il3 | interleukin 3 | 1.42 | NM_010556 | 0.03 |
| Irgm1 | immunity-related GTPase family M member 1 | 2.04 | NM_008326 | 0.05 |
| Irgm2 | immunity-related GTPase family M member 2 | 2.84 | - | 0.01 |
| Map1lc3a | microtubule-associated protein 1 light chain 3alpha | 2.18 | NM_025735 | 0.01 |
| Npc1 | Niemann Pick type C1 | 1.88 | NM_008720 | 0.04 |
| Rab24 | RAB24, member RAS oncogene family | 2.03 | NM_009000 | 0.02 |
| Tsc1 | tuberous sclerosis 1 | 1.44 | NM_022887 | 0.04 |
| Tsc2 | tuberous sclerosis 2 | 1.52 | NM_011647 | 0.02 |
| Wipi1 | WD repeat domain, phosphoinositide interacting 1 | 1.26 | NM_145940 | 0.05 |
| Known Genes Associated with Mitophagy | ||||
| Bnip2 | BCL2/adenovirus E1B interacting protein 2 | 1.51 | NM_016787 | 0.01 |
| Bnip3 | BCL2/adenovirus E1B interacting protein 3 | 1.75 | NM_009760 | 0.02 |
| Bnipl | BCL2/adenovirus E1B 19 kD interacting protein like | 1.40 | NM_134253 | 0.01 |
| Park7 | Parkinson disease (autosomal recessive, early onset) 7 | 1.97 | NM_020569 | 0.02 |
| Pacrgl | PARK2 co-regulated-like | 1.31 | NM_025755 | 0.04 |
| Genes Associated with Mitophagy in a New Yeast Genetic Screen | ||||
| Mon1b | MON1 homolog b (yeast) | 1.96 | NM_173015 | 0.03 |
| Mon2 | MON2 homolog (yeast) | 2.10 | NM_153395 | 0.02 |
| Vps41 | vacuolar protein sorting 41 (yeast) | 1.61 | NM_172120 | 0.003 |
| Dnm1 | dynamin 1 | 1.60 | NM_010065 | 0.007 |
| Mak | male germ cell-associated kinase | 1.49 | NM_001145803 | 0.004 |
| Rpl13a | ribosomal protein L13a | 1.71 | - | 0.03 |
| Abcc2 | ATP-binding cassette, sub-family C (CFTR/MRP), member 2 | 2.05 | NM_013806 | 0.02 |