Table 7.
Upregulation of gene transcripts encoding lysosomal proteins in the tumor stroma from human breast cancer patients
| Gene | Description | Tumor stroma | Recurrence-stroma | Metastasis-stroma | |
| Stromal Expresssion of Lysosome Associated Proteases | |||||
| Ctsb | cathepsin B | 4.11E-36 | 3.27E-02 | 1.39E-02 | |
| Ctsz | cathepsin Z | 5.62E-24 | |||
| Ctsk | cathepsin K | 3.28E-20 | |||
| Ctso | cathepsin O | 1.49E-19 | |||
| Ctse | cathepsin E | 1.66E-19 | 3.78E-03 | ||
| Ctss | cathepsin S | 3.70E-18 | |||
| Ctsw | cathepsin W | 1.94E-15 | |||
| Ctsf | cathepsin F | 7.03E-14 | |||
| Ctsh | cathepsin H | 7.21E-12 | |||
| Ctsg | cathepsin G | 1.32E-11 | 4.03E-04 | ||
| Lgmn | legumain | 4.24E-02 | |||
| Stromal Association of Other Lysosomal Associated Proteins | |||||
| Atp6ap1 | AtPase, H+ transporting, lysosomal accessory protein 1 | 2.11E-27 | |||
| Lamp2 | lysosomal-associated membrane protein 2 | 3.75E-24 | |||
| Atp6v0a2 | AtPase, H+ transporting, lysosomal V0 subunit A2 | 1.06E-22 | |||
| Lamp3 | lysosomal-associated membrane protein 3 | 3.09E-21 | |||
| Atp6v0e | AtPase, H+ transporting, lysosomal V0 subunit E | 1.39E-20 | 4.85E-02 | ||
| Atp6v0d2 | AtPase, H+ transporting, lysosomal V0 subunit D2 | 2.00E-20 | |||
| Atp6v1b1 | AtPase, H+ transporting, lysosomal V1 subunit B1 | 8.45E-20 | 6.56E-03 | ||
| Atp6v0d1 | AtPase, H+ transporting, lysosomal V0 subunit D1 | 1.32E-19 | |||
| Lipa | lysosomal acid lipase A | 4.83E-19 | |||
| Atp6v1g2 | AtPase, H+ transporting, lysosomal V1 subunit G2 | 7.64E-18 | |||
| Atp6v1a | AtPase, H+ transporting, lysosomal V1 subunit A | 8.45E-17 | 1.51E-08 | ||
| Atp6v1c2 | AtPase, H+ transporting, lysosomal V1 subunit C2 | 7.64E-16 | 5.72E-03 | ||
| Lamp1 | lysosomal-associated membrane protein 1 | 1.22E-15 | 8.38E-04 | ||
| Tcirg1 | T-cell, immune regulator 1, AtPase, H+ transporting, lysosomal V0 protein A3 | 1.26E-14 | 1.96E-02 | ||
| Atp6v1c1 | AtPase, H+ transporting, lysosomal V1 subunit C1 | 1.62E-13 | |||
| Laptm4a | lysosomal-associated protein transmembrane 4A | 2.89E-13 | |||
| Atp6v0a1 | AtPase, H+ transporting, lysosomal V0 subunit A1 | 5.35E-12 | 5.93E-03 | ||
| Lyst l | ysosomal trafficking regulator | 1.20E-11 | |||
| Atp6v1g3 | AtPase, H+ transporting, lysosomal V1 subunit G3 | 2.43E-08 | |||
| Atp6v0a4 | AtPase, H+ transporting, lysosomal V0 subunit A4 | 4.37E-07 | 2.34E-03 | ||
| Laptm4b | lysosomal-associated protein transmembrane 4B | 3.54E-02 | |||