Table 8.
Upregulation of telomerase and selected redox-related gene transcripts in the tumor stroma from human breast cancer patients
| Gene | Description | Tumor stroma | Recurrence-stroma | Metastasis-stroma | |
| Telomerase-Related | |||||
| Rtel1 | regulator of telomere elongation helicase 1 | 6.03E-06 | |||
| Terf1 | telomeric repeat binding factor 1 | 4.49E-02 | |||
| Terf2 | telomeric repeat binding factor 2 | 3.56E-08 | 1.63E-02 | ||
| Tert | telomerase reverse transcriptase | 1.34E-11 | 1.23E-02 | 2.17E-02 | |
| Tep1 | telomerase associated protein 1 | 2.21E-07 | 5.05E-05 | ||
| Tinf2 | Terf1 (TRF1)-interacting nuclear factor 2 | 8.40E-06 | |||
| Glutathione-Related Genes | |||||
| Gpx1 | glutathione peroxidase 1 | 1.77E-31 | |||
| Mgst3 | microsomal glutathione S-transferase 3 | 1.29E-19 | |||
| Gpx6 | glutathione peroxidase 6 | 1.66E-19 | |||
| Gsta3 | glutathione S-transferase, alpha3 | 1.00E-15 | 9.54E-04 | ||
| Gpx7 | glutathione peroxidase 7 | 1.93E-15 | |||
| Gstt2 | glutathione S-transferase, theta2 | 1.07E-14 | |||
| Gpx5 | glutathione peroxidase 5 | 5.30E-14 | 4.33E-03 | ||
| Gstcd | glutathione S-transferase, C-terminal domain containing | 6.17E-11 | |||
| Gstm5 | glutathione S-transferase, mu5 | 8.78E-08 | 4.56E-02 | 7.39E-03 | |
| Gpx2 | glutathione peroxidase2 | 9.98E-08 | 3.10E-02 | ||
| Gstm3 | glutathione S-transferase, mu3 | 2.87E-02 | |||
| Haghl | hydroxyacylglutathione hydrolase-like | 4.02E-02 | |||
| Gstm4 | glutathione S-transferase, mu4 | 1.44E-02 | |||
| Mgst1 | microsomal glutathione S-transferase 1 | 1.44E-02 | |||
| Gpx3 | glutathione peroxidase 3 | 4.32E-02 | |||
| Oxidative Stress and Hypoxia | |||||
| Oxsr1 | oxidative-stress responsive 1 | 5.45E-20 | 1.43E-02 | ||
| Hif3a | hypoxia inducible factor 3alpha subunit | 2.27E-15 | 2.15E-04 | ||
| Hyou1 | hypoxia upregulated 1 | 3.45E-14 | 2.85E-04 | ||
| Hif1an | hypoxia-inducible factor 1alpha subunit inhibitor | 8.86E-12 | 1.95E-03 | 6.98E-03 | |
| Hif1a | hypoxia inducible factor 1alpha subunit | 2.10E-06 | |||
| Redoxin's | |||||
| Txndc3 | thioredoxin domain containing 3 (spermatozoa) | 9.19E-27 | |||
| Txnl4a | thioredoxin-like 4A | 5.81E-22 | |||
| Txndc2 | thioredoxin domain containing 2 (spermatozoa) | 3.65E-16 | |||
| Prdx3 | peroxiredoxin 3 | 9.85E-12 | 2.02E-03 | ||
| Txnrd2 | thioredoxin reductase 2 | 1.21E-11 | |||
| Glrx5 | glutaredoxin 5 homolog (S. cerevisiae) | 2.02E-10 | |||
| Nxn | nucleoredoxin | 3.48E-04 | |||
| Txnip | thioredoxin interacting protein | 1.77E-03 | |||
| Glrx | glutaredoxin | 2.70E-02 | |||
| Txnl1 | thioredoxin-like 1 | 2.99E-02 | |||
| Prdx2 | peroxiredoxin 2 | 2.18E-02 | |||
| Prdx6 | peroxiredoxin 6 | 3.62E-02 | |||
| Fdxr | ferredoxin reductase | 4.29E-02 | |||
| Mterfd2 | MTERF domain containing 2 | 8.13E-23 | |||
| Mterfd1 | MTERF domain containing 1 | 3.81E-02 | 1.32E-02 | ||