Table 9.
Transcriptional profiling of human breast cancer tumor stroma: ADMA and BHB metabolism
| Gene symbol | Tumor stroma | Recurrence-stroma | Metastasis-stroma | Cav-1 KO MSCs | |
| ADMA Production | Fold-change | p-value | |||
| PRMT2 | 1.35E-02 | 1.68 | 0.1 | ||
| PRMT7 | 1.76E-02 | ||||
| PRMT8 | 2.41E-18 | 3.04E-02 | 1.56 | 0.02 | |
| ADMA Degradation | |||||
| DDAH1 | 2.36E-10 | 1.90 | 0.006 | ||
| DDAH2 | 7.25E-16 | 1.46 | 0.005 | ||
| Ketone Production | |||||
| ACLY | 1.55E-02 | 2.50E-02 | 2.19 | 0.02 | |
| HMGCS1 | 1.34 | 0.04 | |||
| HMGCS2 | 3.91E-19 | 3.30E-02 | 1.52 | 0.04 | |
| HMGCL | 2.24 | 0.03 | |||
| HMGCLL1 | 3.19E-13 | 5.95E-04 | |||
| BDH1 | 1.04E-06 | 6.46E-03 | 1.38 | 0.04 | |
| BDH2 | 3.54E-02 | ||||
| Ketone Re-Utilization | |||||
| ACAT1 | |||||
| ACAT2 | 1.57 | 0.1 | |||
| OXCT1 | 1.25 | 0.04 | |||
| OXCT2 | 1.38 | 0.05 | |||
| Nitric Oxide Production | |||||
| NOS1 | 2.02E-13 | 1.82E-04 | |||
| NOS2 | 1.36 | 0.05 | |||
| NOS3 | 1.36E-06 | 1.21E-02 | 1.65 | 0.05 | |
| NOSIP | 3.04E-02 | 1.59 | 0.03 | ||
| NOSTRIN | 2.09E-04 | 1.21 | 0.02 | ||
Note that for ADMA production, only PRMT genes that were upregulated in the tumor stromal gene sets or Cav-1 KO MSCs are listed. MSCs, mesenchymal stem cells.