Figure 15.

BNIP3L is highly increased in the stroma of human breast cancers that lack stromal Cav-1. Paraffin-embedded sections of human breast cancer samples lacking stromal Cav-1 were immuno-stained with antibodies directed against BNIP3L (ab59908; Abcam). Slides were then counter-stained with hematoxylin. Note that BNIP3L is highly expressed in the stromal compartment of human breast cancers that lack stromal Cav-1. The boxed area shown at higher magnification reveals punctate staining, consistent with mitochondrial and/or lysosomal localization. Original magnification, 40x and 60x, as indicated.