Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2011 Mar;178(3):1245–1256. doi: 10.1016/j.ajpath.2010.11.070

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2011 American Society for Investigative Pathology. Published by Elsevier Inc. All rights reserved.

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which allows reusers to copy and distribute the material in any medium or format in unadapted form only, for noncommercial purposes only, and only so long as attribution is given to the creator.

PMC Copyright notice

Progesterone withdrawal results in elevated IL-8 mRNA expression but only under hypoxic conditions. A: Significant up-regulation of IL-8 mRNA expression was observed in proliferative endometrium (n = 5, five different women) subjected to in vitro progesterone withdrawal (Pw/d) in the presence of hypoxia (*P < 0.05). This effect was abrogated by the addition of 8.4 μmol/L of indomethacin (Indo), a COX inhibitor. B: Insertion of the LNG-IUS, with consequent local progesterone deprivation analogous to local progesterone withdrawal, resulted in a significant increase in IL-8 mRNA (P < 0.05). Note logarithmic scale on the y axis. Immunohistochemical staining of IL-8 in mid secretory phase endometrium before IUS insertion (C) and in endometrium from the same woman four months after IUS insertion (D). GE, glandular epithelial cells; St, stromal compartment; dSt, decidualized stromal cells. Arrows indicate perivascular cells.