Table 1.

Mouse IL-4-associated macrophage gene signatures

Gene annotations and functional classifications*	Gene symbols	Other names	Entrez gene ID	Human homologs	Reference
Endocytosis and protein transport
CD36 antigen	Cd36	Scarb3	12491	CD36**	17, 137
Folate receptor 2 (fetal)	Folr2		14276	FOLR2	35
Mannose receptor, C type 1	Mrc1	MMR; MR; CD206	17533	MRC1**	17, 35
Immunity and defense
Interferon gamma inducible protein 30	Ifi30		65972	IFI30	34
Serum amyloid A 3	Saa3		20210	SAA1	33
Selenoprotein P, plasma, 1	Sepp1	Se-P	20363	SEPP1**	35
Chemotaxis
Chemokine (C-C motif) ligand 2	Ccl2	MCP-1, JE	20296	CCL13**	138
Chemokine (C-C motif) ligand 9	Ccl9	Scya9	20308	-	34
Chemokine (C-C motif) ligand 17	Ccl17	Tarc	20295	CCL17	17, 139
Chemokine (C-C motif) ligand 22	Ccl22	MDC	20299	CCL22**	17
Cell adhesion
C-type lectin domain family 10, member A	Clec10a	Mgl1	17312	CLEC10A	35
Cadherin 1	Cdh1	Ecad	12550	CDH1	35
Macrophage galactose N-acetyl-Galactosamine specific lectin 2	Mgl2		216864	CLEC10A	35
Amino acid and protein modification
Arginase, liver	Arg1		11846	ARG1	17, 34, 35
Heat shock protein 5	Hspa5		14828	HSPA5	34
Tissue inhibitor of metalloproteinase 1	Timp1		21857	TIMP1	34
Carbohydrate metabolism
Chitinase 3-like 3	Chi3l3	Ym1	12655	-	34, 35
Chitinase 3-like 4	Chi3l4	Ym2	104183	-	35
Others
Resistin like alpha	Retnla	Fizz1; RELMa	57262	-	33, 35
Triggering receptor expressed on myeloid cells 2	Trem2		83433	TREM2	35

^*Genes are categorized based on the Gene Ontology (GO) classes of biological processes in the Database for Annotation, Visualization and Integrated Discovery (DAVID), NIH, and listed alphabetically.

^**Gene upregulation has been validated in both human and murine macrophages.