Figure 5.

Loss of Cdk4 in hematopoietic cells does not alter response to allergen challenge. (A) Schematic cartoon of allergen challenge. Cdk4^−/− and WT bm chimeric mice were sensitized and challenged with PBS or OVA. (B) Total cell counts and counts for macrophages, eosinophils, neutrophils and lymphocytes in bronchoalveolar lavage fluid are shown. N = 10/group. (C) Invasive measurement of airway reactivity to i.v. acetylcholine. Results are means ± SEM (n = 4 to 5). Data is expressed as dose response to Acetylcholine (µg/g body weight (BW)).