Figure 5.
Glucose-stimulated secretion of insulin and potential mechanisms of interference by selected medications. Also, the potential mechanism by which GLP-1 may overcome these hyperglycemic effects. Adapted with permission from Van Raalte DH, Ouwens DM, Diamant M. Novel insights into glucocorticoid-meidated diabetogenic effects: towards expansion of therapeutic options? Eur J Clin Invest. 2009;39(2):81–93.50 Copyright © 2009 John Wiley and Sons.
Abbreviations: AC, adenyl cyclase; ATP, adenosine triphosphate; cAMP, cyclic adenosine monophosphate; GIP, glucose-dependent insulinotropic polypeptide; GK, glucokinase; GLP-1, glucagon-like peptide-1; GLUT2, glucose transporter 2; PKA, protein kinase A; SUR, sulfonylurea receptor; TCA, tricaroboxylic acid (Kreb’s cycle).