Weight change stratified by baseline body mass index in previously insulin-naïve patients adding basal insulin to oral antidiabetic therapy. A) In a comparative treat-to-target trial. B) In the observational PREDICTIVE study. Figure 3a reprinted from Philis-Tsimikas A. Tolerability, safety and adherence to treatment with insulin detemir injection in the treatment of type 2 diabetes. Patient Prefer Adherence. 2008;2:323–332.79 Copyright 2008, with permission from Dove Medical Press Ltd. Figure 3b reprinted from Dornhorst A, Lüddeke HJ, Sreenan S, et al; PREDICTIVE Study Group. Insulin detemir improves glycaemic control without weight gain in insulin-naïve patients with type 2 diabetes: Subgroup analysis from the PREDICTIVE study. Int J Clin Pract. 2008;62:659–665.81 Copyright © 2008, with permission from John Wiley & Sons, Inc.