Figure 3.

SCIO-469 accelerated wound healing in db/db mice. (A) Digital photographic imaging data showed that wound healing was significantly (*p < 0.001) impaired in the diabetic db/db mice (open circles) when compared to the nondiabetic db/+ mice (filled circles): (B) Establishing the suitability of this model. Promogran™ (open squares) significantly (*p < 0.05) accelerated wound healing in db/db mice at all time points when compared with the db/db mice (vehicle-treated group) (open circles); (C) SCIO-469 (open triangles) significantly (*p < 0.01) accelerated wound closure in db/db mice at all time points when compared to the vehicle-treated group (open circles); (D) SCIO-469-treated db/db wounds (solid bar) were significantly smaller (ie, reduced % of wound area remaining) on day 7 (**p < 0.01) when compared to the vehicle treated group (dotted bar) and superior to the Promogran™-treated group (*p < 0.05 when compared to the vehicle-treated group) (open bar). The hatched bar represents wound healing in nondiabetic mice. Values are reported as the mean ± SE; n = 8.