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. Author manuscript; available in PMC: 2011 Mar 3.
Published in final edited form as: Prog Drug Res. 2011;67:107–124. doi: 10.1007/978-3-7643-8989-5_6

Fig. 3.

Fig. 3

Demethylation by oxidation. (a) Scheme of the demethylation reaction catalyzed by LSD1. (b) Schematic representation of human LSD1 domain organization. The oxidase domain contains an atypical insertion of the Tower domain not found in other oxidases. The solution NMR structure of the SIWRM domain of LSD1 is shown in red [65]. Crystal structure of LSD1 (residues 171–836 in blue)-CoREST (residues 308–440 in red ) in complex with H3 peptide (residues 1–16 in green), and the FAD cofactor is shown as a yellow ball-and-stick [71]