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. Author manuscript; available in PMC: 2011 Mar 3.
Published in final edited form as: Prog Drug Res. 2011;67:107–124. doi: 10.1007/978-3-7643-8989-5_6

Fig. 4.

Fig. 4

Demethylation by hydroxylation. (a) Mechanisms of demethylation of 3-methylcytosine by AlkB (top) and of methyl-lysine by Jumonji-domain proteins (bottom). (b) Coordinations of Fe2+ (sphere), α-ketoglutarate in JMJD2A (in gray), and KIAA1718 (in green). (c) Schematic representation of JMJD2A domain organization, including the structures of the N-terminal Jumonji (ribbons) [85] and the C-terminal double Tudor domain (surface representation) [87]