. 2011 Jan 1;10(1):156–165. doi: 10.4161/cc.10.1.14457

Table 1.

Relative fitness, maximal growth rate, and flow cytometry analysis of cell cycle progression for 49 long-lived mutants

Strain	Lifespan (% Change)	Relative fitness (RF)	Doubling time (min)	G₁ Delay (%)
afg3	20.4	−7.00 ± 0.00^**	128.5 ± 2.9^**	45.8 ± 9.8^**
alg12	24.7	−0.37 ± 0.44	92.6 ± 0.2	−22.1 ± 1.6^**
dbp3	33.6	−6.78 ± 0.65^**	116.5 ± 1.6^**	44.8 ± 5.7^**
elp4	34.8	−7.00 ± 0.00^**	116.8 ± 1.4^**	5.8 ± 11.3
fob1	23.5	0.27 ± 0.16	92.7 ± 1.6	8.6 ± 6.8
gpa2	36.1	−2.12 ± 0.28^**	107.5 ± 2.3^**	6.8 ± 2.3^*
gpr1	21.1	0.62 ± 0.52	93.8 ± 0.8	4.4 ± 3.6
hse1	25.5	−0.94 ± 1.13	90.3 ± 0.4	9.0 ± 13.0
idh1	35.1	−1.02 ± 0.38^*	94.1 ± 1.3	−5.4 ± 5.7
idh2	25.3	−1.37 ± 0.16^**	94.3 ± 1.0	9.6 ± 11.0
inp51	13.2	0.05 ± 0.09	91.6 ± 0.5	11.9 ± 8.7
inp53	30.7	−0.38 ± 0.11	93.4 ± 3.1	3.4 ± 9.4
msw1	30.2	−0.41 ± 0.28	90.3 ± 0.9	−3.9 ± 2.2^*
pkh2	22.2	3.36 ± 1.86^**	93.4 ± 1.8	1.7 ± 7.4
pmr1	37.0	−5.18 ± 0.74^**	109.4 ± 4.4^**	−4.3 ± 11.8
rei1	37.5	−3.96 ± 1.84^**	129.3 ± 6.2^**	45.4 ± 12.5^**
rim1	13.7	0.16 ± 0.54	92.9 ± 1.9	−3.6 ± 2.4
rpl13a	27.0	−6.75 ± 0.22^**	115.3 ± 2.8^**	46.6 ± 5.0^**
rpl19a	28.4	−3.92 ± 0.79^**	117.2 ± 3.7^**	52.5 ± 4.7^**
rpl21b	54.5	−6.36 ± 0.78^**	112.3 ± 2.7^**	46.0 ± 3.7^**
rpl22a	34.5	−7.00 ± 0.00^**	144.8 ± 6.3^**	73.6 ± 8.8^**
rpl23a	29.5	−7.00 ± 0.48^**	115.1 ± 2.7^**	30.7 ± 11.2^**
rpl29	28.0	−4.22 ± 0.44^**	109.0 ± 3.1^**	41.0 ± 0.9^**
rpl31a	34.1	−7.00 ± 0.00^**	287.7 ± 3.4^**	127.2 ± 16.9^**
rpl37b	35.1	−6.72 ± 0.15^**	116.8 ± 2.3^**	46.0 ± 6.6^**
rpl43b	37.5	−2.71 ± 1.02^**	96.0 ± 1.0^*	23.7 ± 0.5^**
rpl6b	13.9	−5.21 ± 1.79^**	117.2 ± 3.9^**	48.5 ± 7.2^**
rpl7a	39.3	−5.79 ± 0.66^**	112.3 ± 2.0^**	30.1 ± 2.7^**
rpl9a	29.4	−6.41 ± 0.31^**	111.6 ± 3.8^**	54.1 ± 2.8^**
rpp2b	54.2	−7.00 ± 0.00^**	144.9 ± 2.3^**	68.0 ± 2.7^**
sam1	37.9	−1.31 ± 0.71^*	92.9 ± 2.7	−2.6 ± 2.4
sch9	42.8	−7.00 ± 0.00^**	170.2 ± 3.5^**	87.0 ± 3.2^**
sip2	18.0	0.42 ± 0.39	93.4 ± 1.9	6.3 ± 7.8
SIR2OX	25.0	0.26 ± 0.16	91.4 ± 1.9	3.5 ± 5.9
sis2	47.8	−0.68 ± 0.29	95.2 ± 0.7^*	6.6 ± 6.3
sok1	37.2	−0.93 ± 0.38^*	94.7 ± 3.2	6.1 ± 3.0^*
sps1	23.8	−3.93 ± 1.03^**	106.0 ± 5.9^*	−4.4 ± 6.3
spt4	46.3	−6.53 ± 0.47^**	118.2 ± 5.5^**	−49.5 ± 14.0^**
tif1	13.1	−0.07 ± 0.55	94.3 ± 1.4	29.4 ± 5.0^**
tif2	18.1	−0.02 ± 0.21	90.6 ± 1.5	18.3 ± 2.7^**
tif4631	18.0	−4.62 ± 1.03^**	111.6 ± 3.1^**	27.8 ± 4.2^**
tis11	32.2	0.81 ± 0.30^**	92.2 ± 2.3	−5.5 ± 3.5
tma19	31.8	−1.25 ± 0.67^*	98.0 ± 3.8	28.6 ± 8.4^**
tor1	30.8	−0.85 ± 0.78	92.8 ± 1.9	0.5 ± 1.2
ure2	29.5	−5.40 ± 0.82^**	95.7 ± 3.5	3.6 ± 5.8
ybr238c	49.7	−3.57 ± 0.15^**	98.2 ± 2.4^*	9.7 ± 5.2^*
ybr255w	33.9	−0.29 ± 0.18	96.8 ± 1.9^*	−0.9 ± 5.1
ybr266c	37.0	−6.96 ± 0.04^**	122.6 ± 2.6^**	63.6 ± 4.0^**
ypt6	30.3	−4.02 ± 0.36^**	107.0 ± 3.7^**	17.1 ± 1.2^**
LYS2	N/A	−0.11 ± 0.12	90.0 ± 0.8	−0.6 ± 0.4
BY4742	N/A	N/A	91.0 ± 1.3	0.0 ± 1.6

Life span percent change is the relative increase in life span for each mutant compared to experiment matched wild type controls. G₁ delay is shown as the percent increase in cells in G₁ during log phase for each mutant relative to wild type. Mean values and standard error of the mean (s.e.m) for at least triplicate biological replicates for each assay are shown.

p < 0.05

^**

p < 0.01.