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. 2011 Feb 14;108(9):3695–3700. doi: 10.1073/pnas.1017015108

Fig. 5.

Fig. 5.

Mimototopes enable typical interaction with allogeneic MHC. Interactions of TCR with allogeneic MHC and mimotopes were mapped by using a panel of CHO cells expressing I-Ek with individual disruptive mutations. T-cell hybrid responses were assessed by ELISA measurement of IL-2 production in 24-h culture supernatants. Inhibition of alloreactivity was defined as response to mimotopes presented by mutant I-Ek molecules divided by response to mimotopes presented by wild-type I-Ek. Data are averages of three independent experiments.