Table 1.

TLR relative expression in stimulated human monocytes

	Bb, 10:1 MOI
n = 6	No inhibitor	TLR8-inhibited	Pam3CSSNA,10 μg	R848,1 μg
TLR2	3.1 ± 0.5	1.9 ± 0.2*	2.8 ± 1.7	2.2 ± 0.4
TLR8	5.8 ± 0.7	−1.5 ± 0.6*	−0.4 ± 1.9	14.2 ± 4.3
TLR7	1.4 ± 0.1	−0.4 ± 1.2*	−1.3 ± 0.2	3.6 ± 2.7
TLR9	−3.6 ± 0.9	−2.5 ± 0.7	−1.5 ± 0.5	−3.1 ± 1.3

Values represent relative changes in gene expression compared with GAPDH. MOI, multiplicity of infection.

*P < 0.05 (Mann–Whitney U test). Comparison analysis between TLR8-inhibited and -uninhibited Bb-stimulated monocytes.