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. 2011 Feb 14;108(9):3636–3641. doi: 10.1073/pnas.1016524108

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Fig. 4. — Effect of MOF and HDACi treatment on body weight, survival, and PC numbers. (A) Mof^F/F/Pcp2-Cre⁺ (Left) and Mof^F/F/Pcp2-Cre⁻ (Right) mice at postnatal day 45. (B) Body weight of Mof^F/F/Pcp2-Cre⁺ mice decreased after postnatal day 30. (C) Comparison of food intake by Mof^F/F/Pcp2-Cre⁺ and Mof^F/F/Pcp2-Cre⁻ mice. (D) Survival of Mof^F/F/Pcp2-Cre⁺ mice was significantly decreased relative to Mof^F/+/Pcp2-Cre⁻ mice. Mice with PC-specific knockout of the mMof gene (Mof^F/F/Pcp2-Cre⁺) die at 61 ± 12 d after birth, whereas Mof^F/F/Pcp2-Cre⁻ mice remain healthy. (E) TSA has a positive effect on the cumulative survival of Mof^F/F/Pcp2-Cre⁺ mice but not Mof^F/F/Pcp2-Cre⁻ mice. (F) TSA affects the frequency of PCs in Mof^F/F/Pcp2-Cre⁺ mice but not in Mof^F/F/Pcp2-Cre⁻ mice.