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. 2011 Feb 9;108(9):3791–3796. doi: 10.1073/pnas.1014715108

Fig. 3.

Fig. 3.

A low concentration of rapamycin selectively blocks L-LTP only in slices from mTOR+/− mice. Rapamycin (10 nM) blocked L-LTP in slices from mTOR+/− mice (LTP magnitude at 30 min, vehicle 77 ± 11%, rapamycin 69 ± 18%, P > 0.05; LTP magnitude at 220 min, vehicle 76 ± 12%, rapamycin 9 ± 14%, P < 0.01; B), but not the L-LTP-induced by four tetanic trains in WT slices (LTP magnitude at 30 min, vehicle 108 ± 16%, rapamycin 90 ± 10%, P > 0.05; LTP magnitude at 220 min, vehicle 84 ± 6%, rapamycin 86 ± 8%, P > 0.05; A). (C) In WT slices, a much higher concentration of rapamcyin (1 μM) was required to block L-LTP (LTP magnitude at 20 min, vehicle 96 ± 15%, rapamycin 86 ± 18%, P < 0.05; LTP magnitude at 220 min, vehicle 83 ± 11%, rapamycin 33 ± 10%, P > 0.05). Horizontal bars indicate the period of incubation with rapamycin.