Table 2.

rs8099917 TT genotype is associated with higher viral clearance rate, early surge of viral titer after therapy, and higher SVR rate

	Rs8099917
	TT genotype	GT genotype	P value
SVR	67	7	0.0037*
No SVR	10	7
Clearance rate	3.56 ± 3.51	3.79 ± 7.21	0.9070†
			0.0234‡
Clearance rate (excluding extreme value, >20)	3.22 ± 2.02	1.92 ± 1.75	0.0259†
			0.0114‡
Log10 (production rate)	10.74 ± 1.17	10.34 ± 1.07	0.2210†
			0.2315‡
Time of viral titer elevation, d			0.0502*
0.33	20	3
0.5	18	1
0.67	10	4
1.0	0	1
1.5	1	0
2.0	0	1
3.0	1	0
Estimated time of maximal viral load with elevation, d	0.21 ± 0.14	0.40 ± 0.61	0.36†

Data are shown by mean ± SD or case number. SVR was defined as undetectable serum HCV RNA 24 wk after discontinuation of treatment, and we used 34 IU/mL as the undetectable level of serum HCV RNA.

*Fisher's exact test.

^†Student's t test.

^‡Kolmogorov–Smirnov test.