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. Author manuscript; available in PMC: 2012 Mar 1.
Published in final edited form as: Cancer Res. 2011 Jan 7;71(5):1752–1762. doi: 10.1158/0008-5472.CAN-10-3573

Figure 3.

Figure 3

Differential levels of H3K27me3 and DNA methylation in PI3K/AKT-repressed loci. A, as shown in Fig. 2C, 40 genes were randomly selected from PI3K/AKT-suppressed loci and subjected to ChIP- and meDIP-qPCR in 21 cancer lines. Enrichment values of epigenetic marks were transformed by taking the square root and plotted in figures. Box-plot shows distribution of levels for H3K27me3 (upper) and DNA methylation (lower) across all samples. The bottom and top of the box, as well as the line in between, indicate the lower, upper and median quartiles of data, respectively. Representative data were derived from at least two independent experiments. B, heatmaps show H3K27me3 (pink) and DNA methylation (blue) of 26 genes in panel A.