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. 2010 Nov 16;19(3):442–449. doi: 10.1038/mt.2010.240

Figure 5.

Figure 5

Canine factor VIII (cFVIII) activity after two-chain delivery of cFVIII using adeno-associated virus 8 (AAV8) and AAV9 in hemophilia A (HA) dogs. (a) Coatest assay to determine cFVIII activity after two-chain delivery of cFVIII using AAV8 and AAV9. The solid lines represent dogs administered the high dose (1.25 × 1013 vg/v/kg) while the dashed lines represent dogs administered the low dose (6 × 1012 vg/v/kg). The % activity labeled next to each data line is the average activity from all the time points analyzed. (b) WBCT after two-chain delivery of cFVIII using AAV8 and AAV9. The dark gray–shaded region is the range of values for untreated HA dogs (>40 minutes), while the light gray–shaded region represents the normal dog values (8–12 minutes). WBCT, whole-blood clotting time.