Table 4. Associations of BMI, waist circumference and WHR with grade of prostate cancer (high: Gleason grades 8–9; intermediate: Gleason grade 7; low: Gleason grade ⩽6).
| Reference group |
Grade
|
|||||||
|---|---|---|---|---|---|---|---|---|
| Controls | Low | OR (CI) | Intermediate | OR (CI) | High | OR (CI) | P for heterogeneity | |
| BMI | ||||||||
| <25.0 | 1178 | 184 | 1.00 | 67 | 1.00 | 15 | 1.00 | |
| 25.0–29.9 | 2219 | 331 | 0.95 (0.78–1.16) | 129 | 1.04 (0.76–1.40) | 27 | 0.99 (0.52–1.87) | |
| ⩾30.0 | 971 | 117 | 0.76 (0.59–0.97) | 46 | 0.85 (0.58–1.25) | 13 | 1.12 (0.53–2.38) | |
| Trend P-value | 0.045 | 0.444 | 0.822 | 0.67 | ||||
| Waist (cm) | ||||||||
| ⩽91.4 | 1781 | 270 | 1.00 | 95 | 1.00 | 22 | 1.00 | |
| 91.5–99.1 | 1337 | 199 | 0.98 (0.81–1.20) | 74 | 1.02 (0.75–1.40) | 17 | 0.99 (0.52–1.88) | |
| >99.1 | 1465 | 196 | 0.88 (0.72–1.07) | 79 | 1.00 (0.74–1.36) | 18 | 0.96 (0.51–1.80) | |
| Trend P-value | 0.254 | 0.989 | 0.909 | 0.81 | ||||
| WHR | ||||||||
| ⩽0.908 | 1514 | 212 | 1.00 | 86 | 1.00 | 23 | 1.00 | |
| 0.909–0.952 | 1437 | 222 | 1.10 (0.90–1.35) | 89 | 1.11 (0.82–1.51) | 19 | 0.85 (0.46–1.58) | |
| >0.952 | 1539 | 220 | 1.01 (0.83–1.24) | 72 | 0.84 (0.61–1.16) | 15 | 0.64 (0.33–1.23) | |
| Trend P-value | 0.812 | 0.241 | 0.169 | 0.24 | ||||
Abbreviations: BMI=body mass index; CI=confidence interval; OR=odds ratio; WHR=waist-to-hip ratio.
Multinomial logistic regression model adjusted for age, survey centre, family history. All expected cell frequencies >5.
Groupings according to the World Health Organisation categorisation for BMI, and according to the distribution of controls for waist and WHR.