Table 3. Related haematological and biochemical adverse events of all grades and those grade 3 or highera.

Dose level	1		2		3		4		5		5.5		6		7
No. of patients	3		6		6		4		4		7		6		2
Dose	10 mgb		10 mg		20 mg		30 mg		50 mg		60 mg		70 mg		90 mg
Grades	All grades	Grades 3/4	All grade	Grades 3/4	All grades	Grades 3/4	All grades	Grades 3/4	All grades	Grades 3/4	All grades	Grades 3/4	All grades	Grades 3/4	All grades	Grades 3/4
General
Fatigue	0	0	2	0	2	0	1	0	3	0	6	1	4	2	2c	1
GI
Anorexia	0	0	0	0	2	0	0	0	1	0	4	0	3	0	1	0
Altered taste	0	0	0	0	1	0	0	0	0	0	1	0	0	0	1	0
Mucositis	1	0	1	0	0	0	0	0	0	0	0	0	1	0	0	0
Nausea	0	0	0	0	2	0	0	0	2	0	5	0	4	0	2	0
Vomiting	0	0	0	0	1	0	0	0	2	0	4	0	2	0	2c	1
Diarrhoea	0	0	1	0	1	0	1	0	0	0	4	1	0	0	0	0
Constipation	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
Abdominal pain	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
Cardiac
QT prolongation	0	0	1	0	0	0	0	0	0	0	1	0	1	0	1	0
Ventricular bigemini	0	0	1c	0	0	0	0	0	0	0	0	0	0	0	1	0
Ventricular arrythmias (PVCs)	0	0	1c	0	0	0	0	0	0	0	0	0	0	0	1	0
Cardiac dysfunction	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0
Supra ventricular arrythmia	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0
Cardiac ischaemia	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0
Cardiac arrythmia other	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0
Metabolic
Creatinine (raised)	0	0	1	0	1	0	2	0	0	0	2	0	2	0	2	0
Alkaline phophatase (raised)	1	0	5	1	4	1	2	0	2	0	6	0	3	0	1	0
ALT (raised)	0	0	1	0	2	0	2	0	0	0	4	2	1	0	2	0
AST (raised)	1	0	3	0	3	0	1	0	2	0	5	0	2	0	2	0
Bilirubin (raised)	0	0	1	0	1	0	1	0	0	0	2	0	0	0	1	0
CPK	NA	NA	0	0	1	1	1	0	0	0	0	0	1	0	1	0
Hematologic
Anaemia	2	0	6	0	5	1	4	0	4	0	7	0	6	0	2	0
Leukopenia	1	0	2	0	1	0	2	0	1	0	5	1	3	1	1	0
Neutropenia	1	1	1	0	1	0	2	0	1	0	5	0	3	1	1	0
Lymphopenia	0	0	5	2	2	0	2	0	4	2	6	3	4	3	2	0
Thrombocytopenia	0	0	2	0	1	0	0	0	0	0	5	0	6	1	2	0
Others
Myositis	0	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0
Syncope	0	0	0	0	1	1	0	0	0	0	0	0	0	0	0	0

Abbreviations: ALT=alanine transaminase, AST=aspartate transaminase, CPK=creatine phosphokinase; PVCs=premature ventricular contraction.

^aGraded according to CTCAE version 3.0.

^b3 days every 2 weeks.

^cOne or more SAE.