Table 4. Full data on AUC_0−∞, T_1/2, C_max and T_max for SB939 at different dose levels.

			Day 1		Day 3 or 5
Dose level	Dose (mg)	Parameter	Mean	s.d.	Mean	s.d.
1	10a	AUC0–∞ (ng h ml-1)	126.7	23.9	147.3	32.6
		T1/2 (h)	7.1	0.2	8.3	0.7
		Cmax (ng ml-1)	14.6	6.0	18.3	6.4
		Tmax (h)	2.5	0.9	1.3	0.3
2	10	AUC0–∞ (ng h ml-1)	137.2	26.6	187.7	32.7
		T1/2 (h)	8.6	1.5	8.1	2.5
		Cmax (ng ml-1)	19.5	8.1	23.3	11.4
		Tmax (h)	1.1	0.6	1.3	0.6
3	20	AUC0–∞ (ng h ml-1)	243.7	117.1	424.0	235.4
		T1/2 (h)	5.9	2.4	7.7	0.6
		Cmax (ng ml-1)	45.9	28.5	51.3	31.9
		Tmax (h)	1.5	0.9	1.6	0.8
4	30	AUC0–∞ (ng h ml-1)	383.8	131.8	544.5	206.3
		T1/2 (h)	8.6	1.7	8.8	2.1
		Cmax (ng ml-1)	55.8	21.7	74.3	28.9
		Tmax (h)	1.8	0.9	1.6	0.5
5	50	AUC0–∞ (ng h ml-1)	661.3	415.3	793.7	11.2
		T1/2 (h)	5.6	1.3	8.9	1.2
		Cmax (ng ml-1)	124.1	93.5	101.3	5.6
		Tmax (h)	1.6	1.0	1.7	0.3
5.5	60	AUC0–∞ (ng h ml-1)	1028.7	229.4	1625.2	405.5
		T1/2 (h)	6.7	0.4	6.9	1.6
		Cmax (ng ml-1)	209.6	55.3	262.5	65.9
		Tmax (h)	1.2	0.5	1.3	0.4
6	70	AUC0–∞ (ng h ml-1)	1053.8	664.9	1134.3	678.0
		T1/2 (h)	7.0	1.7	6.4	0.7
		Cmax (ng ml-1)	178.2	122.2	159.7	118.8
		Tmax (h)	1.6	0.4	1.5	0.5
7	90	AUC0–∞ (ng h ml-1)	1130.0	43.8	1229.0	—
		T1/2 (h)	6.4	0.5	6.1	—
		Cmax (ng ml-1)	228.9	7.1	116.0	—
		Tmax (h)	1.0	0.0	1.5	—

^a3 days every 2 weeks.