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. 2011 Feb 8;104(5):769–780. doi: 10.1038/bjc.2011.21

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Copyright © 2011 Cancer Research UK

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Effect of AZD1152-HQPA in combination with oxaliplatin on cell growth and apoptosis. HCT116 cells were seeded in 96-well plates. After 24 h, cells were subjected to concurrent dosing schedule (A and B) or a sequential dosing schedule (C). Cells were then stained for cell number by Hoechst and BAK-epitope, an early marker of apoptosis. Images were taken and end points quantified using the Cellomics Arrayscan II platform. Graphs are representative of three independent experiments. Columns, mean; bars, s.e. ^*P<0.05 vs oxaliplatin 0 μM (two-way ANOVA); WO=washout.