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. 2011 Feb 8;104(5):769–780. doi: 10.1038/bjc.2011.21

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Copyright © 2011 Cancer Research UK

This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.

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In vivo effects of AZD1152, gemcitabine and the sequential combination of AZD1152, followed by gemcitabine on MiaPaCa-2 tumour xenografts. (A) Antitumor effect of AZD1152, gemcitabine and their consecutive combination on MIAPaCa-2 tumours xenotransplanted in CD nu/nu mice. The mice were randomised into groups of eight animals. (B) Body weight of MIAPaCa-2 tumour-bearing control mice and mice treated with metronomic AZD1152, gemcitabine and their consecutive combination. Symbols and bars, mean±s.e.m.; ^*P<0.05 vs vehicle-treated controls.