Table 1. Experiment Design.

	Regimen	D-18	D0	4 mo	6 mo	7 mo	9 mo	12 mo	15 mo	Total
1	Untreated	10	20		10*					40
2	2RHZ+4RH				10		30			40
3	2JRZ+2JR			10		20				30
4	2AEtMZ+4EtM				10		20			30
	2AEtMZ+7EtM						10	20		30
	2AEtMZ+10EtM							10	20	30
5	2JZM+2JM			10		20				30
	2JZM+4JM				10		20			30
	2JZM+7JM						10	20		30
6	2JAEtMZ+4JEtM				10		20			30
7	2JAEtZ+4JEt				10		20			30
8	2JAEtM+4JEtM				10		20			30
9	6JM				10		20			30
10	6JZ				10		20			30
	Total	10	20	20	100	40	210	50	20	440

Definition of abbreviations: J = TMC 207, R = Rifampin, M = Moxifloxacin, H = Isoniazid, Z = Pyrazinamide, A = amikacin, Et = ethionamide.

Mice were infected intravenously with 1.1×10⁶ of M. tuberculosis H37Rv.

Day -18: the day after infection, Day 0: start of treatment.

*Mice kept untreated for mortality assessment.

All drugs were given 5 times per week at the following doses: J, 25 mg/kg; R, 10 mg/kg; M, 100 mg/kg; H, 25 mg/kg; Z, 150 mg/kg; A, 150 mg/kg; Et, 50 mg/kg.