Table 2.

Fold change in steroidogenic gene expression by quantitative real-time PCR

Steroidogenic enzyme gene	Difference [log2 (fold change)]
	Normal adrenal	Fetal adrenal	Patient's adrenal tissue
CYP11A1	0 ± 0.30	1.723 ± 0.159	−0.04
CYP21A2	0 ± 0.52	−0.343 ± 0.41	−1.734
CYP17A1	0 ± 0.37	1.07 ± 0.10	0.02
CYB5	0 ± 0.46	0.98 ± 0.20	4.18
HSD3B2	0 ± 0.73	−9.59 ± 0.43	−9.11
CYP11B1	0 ± 0.54	−1.18 ± 0.50	−4.49
CYP11B2	0 ± 0.63	ND	−8.68
AKR1C3	0 ± 0.76	−6.82 ± 0.28	4.73

Results expressed as the log₂ (fold change) are compared to the gene expression seen in fetal adrenal (n = 5), both normalized to normal adult adrenal tissue (n = 5). Data are represented as mean ± sem, normalized to normal adult adrenal, for which values are defined as 0 (using log scale) with sem given to indicate variance.

ND, not detected.