Table 1.
Association analysis of SNPs from T2D GWAS findings with gene expression in transformed lymphocytes of Caucasian subjects
| Gene name | GWAS-SNP | Major/minor allele (D/d) | Genotype count (DD/Dd/dd) | Pa | P(adj)b |
|---|---|---|---|---|---|
| BCL11A | rs10490072 | T/C | 47/29/7 | 0.371 | 0.417 |
| CAMK1D | rs1277970 | A/G | 49/28/5 | 0.868 | 0.799 |
| CDC123 | rs11257622 | T/C | 56/20/7 | 0.592 | 0.546 |
| CDKAL1 | rs7754840 | G/C | 36/40/7 | 0.696 | 0.915 |
| CDKAL1 | rs10946398 | T/G | 36/40/7 | 0.696 | 0.915 |
| CDKN2A | rs10811661 | T/C | 57/24/2 | 0.456 | 0.528 |
| CDKN2A | rs564398 | G/A | 22/42/18 | 0.72 | 0.827 |
| DNAJC11 | rs12137794 | C/T | 68/15/0 | 0.424 | 0.228 |
| FTO | rs8050136 | C/A | 21/43/16 | 0.446 | 0.235 |
| IDE | rs1111875 | G/A | 33/43/7 | 0.798 | 0.958 |
| IDE | rs5015480 | C/T | 33/43/7 | 0.798 | 0.958 |
| PKN2 | rs6698181 | C/T | 32/35/15 | 0.304 | 0.322 |
| SMARCAD1 | rs728989 | C/G | 57/24/2 | 0.478 | 0.450 |
| THADA | rs7578597 | T/C | 70/12/1 | 0.442 | 0.465 |
| VEGFA | rs9472138 | C/T | 33/39/11 | 0.037 | 0.061 |
| WFS1 | rs10010131 | G/A | 30/39/12 | 0.481 | 0.381 |
Total number of individuals vary due to difference in success of genotyping each SNP and respective gene expression analysis.
a
P, statistical significance of genotypic association from analysis of variance analysis (ANOVA).
b
P(adj), statistical significance of genotypic association from mixed effects, general linear regression models and included genotype, gender, and T2D diagnosis as fixed factors.