Table 2.
Association of SNPs from T2D GWAS findings with gene expression in human adipose
| Gene name | SNP | Major/minor allele (D/d) | All |
Caucasian |
||||
|---|---|---|---|---|---|---|---|---|
| Genotype count (DD/Dd/dd) | Pa | P(adj)b | Genotype count (DD/Dd/dd) | Pa | P(adj)b | |||
| ADAMTS9 | rs4607103 | C/T | 85/58/10 | 0.096 | 0.142 | 63/36/7 | 0.817 | 0.791 |
| CAMK1D | rs1277970 | A/G | 109/38/4 | 0.834 | 0.791 | 72/30/3 | 0.705 | 0.502 |
| CDC123 | rs11257622 | T/C | 105/43/5 | 0.711 | 0.655 | 70/33/3 | 0.407 | 0.520 |
| CDKAL1 | rs7754840 | G/C | 59/63/30 | 0.498 | 0.336 | 55/39/11 | 0.425 | 0.784 |
| CDKAL1 | rs10946398 | T/G | 59/63/30 | 0.498 | 0.336 | 55/39/11 | 0.425 | 0.784 |
| DNAJC11 | rs12137794 | C/T | 128/24/0 | 0.546 | 0.601 | 84/22/0 | 0.386 | 0.218 |
| FTO | rs8050136 | C/A | 45/82/26 | 0.946 | 0.791 | 31/56/19 | 0.821 | 0.983 |
| HHEX | rs111875 | G/A | 68/55/30 | 0.818 | 0.963 | 38/43/25 | 0.836 | 0.478 |
| HHEX | rs5015480 | C/T | 58/61/34 | 0.914 | 0.656 | 37/44/25 | 0.937 | 0.641 |
| IDE | rs111875 | G/A | 68/55/30 | 0.63 | 0.463 | 38/43/25 | 0.267 | 0.053 |
| IDE | rs5015480 | C/T | 58/61/34 | 0.684 | 0.333 | 37/44/25 | 0.397 | 0.105 |
| JAZF1 | rs864745 | T/C | 50/74/29 | 0.447 | 0.670 | 21/60/25 | 0.754 | 0.481 |
| NOTCH2 | rs10923931 | G/T | 105/40/8 | 0.222 | 0.184 | 84/19/3 | 0.901 | 0.226 |
| PKN2 | rs6698181 | C/T | 79/59/15 | 0.038 | 0.018 | 44/48/14 | 0.009 | 0.002 |
| PPARG | rs1801282 | C/G | 120/32/1 | 0.094 | 0.233 | 76/29/1 | 0.136 | 0.376 |
| PPARG | rs17036101 | G/A | 138/15/0 | 0.791 | 0.722 | 95/11/0 | 0.169 | 0.054 |
| SMARCAD1 | rs728989 | C/G | 73/55/24 | 0.467 | 0.427 | 68/32/5 | 0.555 | 0.485 |
| SYN2 | rs17036101 | G/A | 138/15/0 | 0.111 | 0.119 | 95/11/0 | 0.001 | 0.001 |
| TCF7L2 (13a+) | rs7903146 | C/T | 70/69/13 | 0.087 | 0.168 | 52/45/8 | 0.358 | 0.751 |
| THADA | rs7578597 | T/C | 115/32/6 | 0.875 | 0.886 | 82/23/1 | 0.599 | 0.977 |
| TSPAN8 | rs7961581 | T/C | 72/64/12 | 0.226 | 0.200 | 51/42/10 | 0.177 | 0.047 |
| VEGFA | rs9472138 | C/T | 83/64/6 | 0.75 | 0.902 | 53/48/5 | 0.209 | 0.744 |
| WFS1 | rs10010131 | G/A | 52/84/11 | 0.101 | 0.115 | 39/56/8 | 0.136 | 0.179 |
Total number of individuals vary due to difference in success of genotyping each SNP and respective gene expression analysis.
a
P, statistical significance of genotypic association from analysis of variance analysis (ANOVA).
b
P(adj), statistical significance of genotypic association from mixed effects, general linear regression models and included age and BMI as covariate and genotype, gender, ethnicity, and T2D diagnosis as fixed factors.