Table 3.
Association of SNPs from T2D GWAS findings with gene expression in human muscle
| Gene name | SNP | Major/minor allele (D/d) | All |
Caucasian |
||||
|---|---|---|---|---|---|---|---|---|
| Genotype count (DD/Dd/dd) | Pa | P(adj)b | Genotype count (DD/Dd/dd) | Pa | P(adj)b | |||
| ADAMTS9 | rs4607103 | C/T | 88/58/12 | 0.664 | 0.274 | 66/38/9 | 0.518 | 0.360 |
| CAMK1D | rs1277970 | A/G | 108/44/4 | 0.762 | 0.724 | 73/36/3 | 0.712 | 0.727 |
| CDC123 | rs11257622 | T/C | 106/46/6 | 0.843 | 0.869 | 71/38/4 | 0.806 | 0.829 |
| CDKAL1 | rs7754840 | G/C | 61/68/29 | 0.534 | 0.835 | 57/45/11 | 0.232 | 0.295 |
| CDKAL1 | rs10946398 | T/G | 61/68/29 | 0.534 | 0.835 | 57/45/11 | 0.232 | 0.295 |
| DNAJC11 | rs12137794 | C/T | 133/25/0 | 0.601 | 0.603 | 90/23/0 | 0.67 | 0.590 |
| FTO | rs8050136 | C/A | 46/84/28 | 0.239 | 0.348 | 32/60/21 | 0.661 | 0.774 |
| JAZF1 | rs864745 | T/C | 53/75/30 | 0.020 | 0.011 | 25/61/27 | 0.098 | 0.086 |
| PKN2 | rs6698181 | C/T | 78/62/18 | 0.00004 | 0.00027 | 44/52/17 | 0.003 | 0.0021 |
| SMARCAD1 | rs728989 | C/G | 72/59/26 | 0.066 | 0.440 | 67/38/7 | 0.948 | 0.937 |
| THADA | rs7578597 | T/C | 116/35/7 | 0.297 | 0.249 | 84/27/2 | 0.091 | 0.058 |
| TSPAN8 | rs7961581 | T/C | 79/60/13 | 0.216 | 0.241 | 58/40/11 | 0.573 | 0.588 |
| VEGFA | rs9472138 | C/T | 85/64/9 | 0.388 | 0.435 | 56/49/8 | 0.282 | 0.392 |
| WFS1 | rs10010131 | G/A | 53/88/11 | 0.055 | 0.055 | 40/61/9 | 0.067 | 0.069 |
Total number of individuals vary due to difference in success of genotyping each SNP and respective gene expression analysis.
a
P, statistical significance of genotypic association from analysis of variance analysis (ANOVA).
b
P(adj), statistical significance of genotypic association from mixed effects, general linear regression models and included age and BMI as covariate and genotype, gender, ethnicity, and T2D diagnosis as fixed factors.