Table 4.

Allelic expression imbalance in genes from T2D GWAS findings

GWAS gene	SNP	Allele	Caucasian		African American
			Z	P	Z	P
BCL11A	rs7569946	A	−1.1	0.271	−0.865	0.387
CAMK1D	rs1644394	A	−4.754	1.99E-06	−2.009	0.045
CDC123	rs1051055	A	−4.176	3.00E-05	−2.859	0.004
CDKAL1	rs1563727	C	−1.338	0.181	−0.254	0.8
CDKN2A	rs3088440	C	−0.135	0.893	−0.241	0.809
DNAJC11	rs1043681a	G	−6.958	3.50E-12	−4.204	2.60E-05
DNAJC11	rs11892	C	−0.543	0.587	−1.793	0.073
PKN2	rs786906	A	−0.219	0.827	−1.253	0.21
SMARCAD1	rs8336a	A	−6.42	1.40E-10	−2.366	0.018
SMARCAD1	rs8026	A	−4.697	2.64E-06	−1.519	0.129
THADA	rs11899823	C	−2.697	0.007	−1.027	0.304
VEGFA	rs2010963a	C	−4.157	3.20E-05	−1.48	0.139
VEGFA	rs10434	A	−1.451	0.147	−1.882	0.06
WFS1	rs1046316	T	−0.703	0.482	−2.258	0.024

AEI was evaluated by comparing expression of one allele in cDNA with quantity of the same allele in genomic DNA of heterozygotes by using nonparametric Wilcoxon sign rank test. Z and P are Z-statistics and two-tailed asymptotic significance from Wilcoxon Signed Rank Test.

^aFirst cSNP tested.