Table 2.
Frequency of Axis I psychiatric illness in 174 women with POI and 100 women with TS (25)
| POI | TS | |
|---|---|---|
| Current diagnosis (n = 39)a | ||
| Mood disorders | ||
| Major depression | 16 (9.2) | 5 |
| First onset | 4 (2.3) | |
| Minor depression | 11 (6.3) | 5 |
| First onset | 1 (0.6) | |
| Dysthymic disorder | 3 (1.7) | 1 |
| Anxiety disorders | ||
| Specific phobia | 3 (1.7) | 2 |
| Social phobia | 3 (1.7) | 2 |
| Generalized anxiety | 3 (1.7) | 2 |
| PTSD | 2 (1.1) | 0 |
| Agoraphobia without panic | 2 (1.1) | 0 |
| Panic disorder | 1 (0.5) | 4 |
| Past diagnosis (n = 113)b | ||
| Mood disorders | ||
| Major depression | 91 (52.3) | 33 |
| Minor depression | 20 (11.4) | 8 |
| Dysthymic disorder | 2 (1.1) | 0 |
| Anxiety disorders | ||
| Panic disorder | 3 (1.7) | 1 |
| PTSD | 7 (4.0) | 5 |
| Eating disorders | ||
| Anorexia nervosa | 2 (1.1) | 5 |
| Bulimia nervosa | 1 (0.5) | 1 |
| Substance abuse disorders | ||
| Alcohol/drug dependence | 3 (1.7) | 3 |
| Lifetime diagnosis (n = 121)c | ||
| Major depression | 95 (54.5) | 36 |
| Any mood disorder | 117 (67.2) | 47 |
| Any anxiety disorder | 24 (14.0) | 15 |
| Any Axis I disorder | 121 (69.5) | 52 |
Values in women with POI are expressed as number (percentage); otherwise all values are expressed as percentage. The numbers of women with POI meeting criteria for an Axis I disorder were tabulated. In the case of recurrent, episodic disorders like depression, the number of women with a lifetime history of depression was calculated using the results of the SCID as follows: the number of women with at least one past episode of depression plus the number of women with a current major depression that was lifetime first-onset. Thus, women with both a current and past episode of depression were not counted twice. Women who were taking antidepressant medication and whose depression was in remission would no longer meet criteria for current major depression; however, the original depressive episode for which they received treatment would be captured by the SCID and, therefore, included in the lifetime prevalences.
Met two diagnostic categories n = 5 (2.9%); current major depression with Dysthymic disorder n = 2; current major depression with PTSD n = 2; current GAD with panic disorder n = 1.
Met two or more diagnostic categories n = 14 (8.0%); major depression, PTSD n = 5; major depression, PTSD, and alcohol dependence n = 1; major depression, panic disorder and anorexia nervosa n = 1; major depression and panic disorder n = 2; major depression drug dependency n = 1; major depression and alcohol dependence n = 1; major depression and anorexia nervosa n = 1; major depression and bulimia nervosa n =1; major depression and minor depression n =1.
Both the lifetime prevalence of any mood disorder and major depression in women with POI (i.e. 67 and 54.5%, respectively) were significantly higher than those previously observed in a sample of adult women with TS (25) (i.e. POI vs. TS: any mood disorder, 67 vs. 47%; χ2 = 10.8; P = 0.001; major depression, 54.5 vs. 36%; χ2 = 8.8; P = 0.003).