Table 1.
Comparison of genotypic frequencies of ER and CYP19 polymorphisms in Caucasian patients diagnosed with CRPC and healthy volunteers (control)
| Polymorphism | Genotype frequencies |
OR (95% CI) | P value | |
|---|---|---|---|---|
| Cases | Controls | |||
| ERα (rs2234693) | ||||
| TT | 25 | 46 | 1.0 (N/A) | 0.010a |
| TC | 75 | 60 | 2.3 (1.3–4.2) | |
| CC | 28 | 20 | 2.6 (1.2–5.5) | |
| ERα (rs2234693) in men <70 yr old | ||||
| TT | 13 | 46 | 1.0 (N/A) | 0.0073a |
| TC | 50 | 60 | 2.9 (1.4–6.1) | |
| CC | 17 | 20 | 3.0 (1.2–7.3) | |
| ERα (rs9340799) | ||||
| AA | 42 | 58 | 1.0 (N/A) | 0.032a |
| AG | 69 | 61 | 1.6 (0.9–2.6) | |
| GG | 18 | 8 | 3.1 (1.2–7.8) | |
| CYP19 (rs700519) | ||||
| CC | 125 | 139 | 1.0 (N/A) | 0.30b |
| CT or TT | 5 | 11 | 0.5 (0.2–1.5) | |
a
P value determined using a χ2 test.
b
P value determined using a two-tailed Fisher's exact test.