Table 3.
Cardiovascular disease risk factors for women and men at baseline and 24 months, by baseline risk factor level
| Women |
Men |
|||||||
|---|---|---|---|---|---|---|---|---|
| Baseline |
24 months |
Baseline |
24 months |
|||||
| Mean (SE) | Mean (SE) | % change | P-value Interaction | Mean (SE) | Mean (SE) | % change | P-value Interaction | |
| SBP, mm Hg | ||||||||
| Normal | 113.9 (1.8) | 115.1 (1.8) | 1.1 | <0.0001 | 119.3 (1.0) | 119.0 (1.1) | −0.25 | <0.0001 |
| High | 121.1 (1.9) | 124.3 (2.0)a | 2.6 | 131.4 (1.3) | 131.7 (1.4) | 0.23 | ||
| DBP, mm Hg | ||||||||
| Normal | 72.6 (1.1) | 72.5 (1.1) | −0.14 | <0.0001 | 78.0 (0.69) | 77.4 (0.70) | −0.78 | <0.0001 |
| High | 76.4 (1.1) | 76.9 (1.2) | 0.10 | 86.0 (0.83) | 83.5 (0.86)a | −3.0 | ||
| TC, mg/dL | ||||||||
| Normal | 186.2 (4.3) | 189.5 (4.4)a | 1.8 | <0.0001 | 193.7 (2.9) | 190.8 (3.0) | −1.5 | <0.0001 |
| High | 240.7 (5.4) | 223.5 (5.6)a | −7.7 | 245.5 (3.9) | 217.2 (4.1)a | −13.0 | ||
| HDL-C, mg/dL | ||||||||
| Normal | 60.0 (1.5) | 58.5 (1.6) | −2.6 | <0.0001 | 48.5 (0.81) | 47.4 (0.84) | −2.3 | <0.0001 |
| Low | 41.0 (1.5) | 43.0 (1.6)a | 4.9 | 35.0 (0.81) | 36.0 (0.83)a | 2.9 | ||
| LDL-C, mg/dL | ||||||||
| Normal | 113.5 (4.0) | 116.3 (4.0) | 2.5 | <0.0001 | 120.2 (2.6) | 119.5 (2.7) | 0.59 | <0.0001 |
| High | 162.7 (5.0) | 147.1 (5.1)a | −10.6 | 165.0 (3.3) | 142.2 (3.4)a | −16.0 | ||
| TC/HDL-C | ||||||||
| Normal | 3.6 (0.14) | 3.7 (0.15) | 2.8 | <0.0001 | 4.0 (0.12) | 4.1 (0.13) | 2.5 | <0.0001 |
| High | 5.5 (0.16) | 5.2 (0.17)a | 5.8 | 6.3 (0.12) | 5.9 (0.12)a | −6.8 | ||
| Triglycerides, mg/dL | ||||||||
| Normal | 97.4 (7.6) | 103.0 (7.8) | 5.7 | <0.0001 | 110.1 (7.4) | 112.6 (7.7) | 2.3 | <0.0001 |
| High | 214.4 (10.3) | 184.2 (11.1)a | −16.4 | 265.7 (9.5) | 220.6 (9.9)a | −20.4 | ||
a
Notes: P < 0.05; All models controlled for group, race, education, age, sex, and clinical site.
Abbreviations: DBP, diastolic blood pressure; HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol; SBP, systolic blood pressure; SE, standard error; TC, total cholesterol.