Table 4.

Relationship between changes in CVD risk factors and 1) changes in fitness, 2) changes in weight, and 3) changes in fitness + weight

	Women				Men
	Model I		Model II		Model I		Model II
	Estimate (SE)	P-value	Estimate (SE)	P-value	Estimate (SE)	P-value	Estimate (SE)	P-value
SBP, mm Hg
Δ Fitness	−0.12 (0.22)	0.60	0.10 (0.23)	0.67	−0.14 (0.15)	0.33	0.03 (0.15)	0.87
Δ Weight	2.9 (0.09)	0.002	0.32 (0.10)	0.002	0.35 (0.12)	0.003	0.34 (0.13)	0.008
DBP, mm Hg
Δ Fitness	−0.12 (0.12)	0.32	0.01 (0.13)	0.96	−0.17 (0.09)	0.06	−0.05 (0.09)	0.60
Δ Weight	0.18 (0.05)	0.0003	0.20 (0.06)	0.0004	0.28 (0.07)	<0.0001	0.26 (0.08)	0.0008
TC, mg/dL
Δ Fitness	−1.22 (0.47)	0.01	−1.09 (0.50)	0.03	−0.72 (0.42)	0.08	−0.22 (0.44)	0.62
Δ Weight	0.27 (0.21)	0.20	0.24 (0.22)	0.28	1.45 (0.33)	<0.0001	1.40 (0.37)	0.0002
HDL-C, mg/dL
Δ Fitness	0.03 (0.19)	0.88	−0.22 (0.19)	0.25	0.31 (0.10)	0.003	0.24 (0.11)	0.04
Δ Weight	−0.32 (0.08)	<0.0001	−0.37 (0.09)	<0.0001	−0.22 (0.08)	0.008	−0.16 (0.09)	0.09
LDL-C, mg/dL
Δ Fitness	−0.81 (0.45)	0.08	−0.54 (0.48)	0.26	−0.28 (0.39)	0.48	−0.11 (0.42)	0.80
Δ Weight	0.36 (0.20)	0.08	0.42 (0.22)	0.05	0.50 (0.32)	0.11	0.51 (0.35)	0.15
TC/HDL-C
Δ Fitness	−0.03 (0.02)	0.13	−0.01 (0.02)	0.50	−0.05 (0.02)	0.004	−0.03 (0.02)	0.20
Δ Weight	0.02 (0.01)	0.01	0.02 (0.01)	0.01	0.08 (0.01)	0.0001	0.07 (0.02)	<0.0001
Triglycerides, mg/dL
Δ Fitness	−2.23 (1.04)	0.03	−1.51 (1.09)	0.17	−3.69 (1.22)	0.003	−1.65 (1.27)	0.19
Δ Weight	1.38 (0.46)	0.003	1.18 (0.49)	0.02	5.88 (0.93)	<0.0001	5.19 (1.05)	<0.0001

Notes: All models controlled for group, race, education, age, sex, and clinical site. Model I tested the effects of Δ Fitness and Δ Weight separately. Model II entered Δ Fitness and Δ Weight in the model simultaneously, testing the independent effects of each.

Abbreviations: DBP, diastolic blood pressure; HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol; SBP, systolic blood pressure; SE, standard error; TC, total cholesterol.