Table 4. Loci with suggestive (p between 5E-07 and 1E-05) evidence for association with anti–dsDNA + SLE identified in the case-only analysis (811 anti–dsDNA + SLE cases compared to 906 anti–dsDNA – SLE cases).
| MAF‡ | MAF‡ | |||||||
| Gene/Region | chr | SNP | position | MA‡ | anti–dsDNA + | anti–dsDNA – | OR (95% CI) | p (λGC = 1.000) |
| NOTCH4/C6orf10 | 6 | rs3130320 | 32331236 | T | 0.46 | 0.39 | 1.39 (1.21–1.60) | 3.15E-06 |
| a | 3 | rs12629106 | 178577774 | T | 0.13 | 0.19 | 0.64 (0.53–0.77) | 3.71E-06 |
| NAALADL2 | 3 | rs1463525 | 176444089 | C | 0.35 | 0.43 | 0.73 (0.63–0.84) | 7.69E-06 |
| STAT4 | 2 | rs7574865 | 191790139 | T | 0.35 | 0.28 | 1.41 (1.21–1.63) | 7.95E-06 |
| TMC2 | 20 | rs6049839 | 2466565 | T | 0.47 | 0.40 | 1.37 (1.19–1.58) | 8.16E-06 |
| HLA-DQA1/HLA-DQA2 | 6 | rs2647012 | 32772436 | A | 0.51 | 0.44 | 1.38 (1.20–1.59) | 8.39E-06 |
‡ MA = minor allele; MAF = minor allele frequency.
a
no known gene within 100 kb.