Figure 3. Experimental data and mechanistic model fits.

Experimental viral load and viral load predicted by the target cell limitation model and CD8 control model. B cell data was missing for 6 of the datasets and so the model with liberated parameter constraints could not be fitted for these animals. The oscillations in the predicted viral load are due to variation in the experimental data underlying the empirical functions describing the dynamics of target and immune cell populations. Smoothing of the input data reduces the fluctuations. Note: all datasets were fitted simultaneously, not individually.