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. 2011 Mar 3;6(3):e14742. doi: 10.1371/journal.pone.0014742

Figure 1. Construction of a catalogue of mixed Feed-Forward regulatory Loops having MYC as master regulator, in which all the regulatory interactions are experimentally validated.

Figure 1

a) Representation of a typical mixed single miRNA/Transcription Factor FFL having MYC as master regulator: MYC regulates a miRNA and together with it, a Joint Target protein-coding gene. According to the arrows direction, the mixed FFLs can be classified as incoherent (type I) or coherent (type II) circuits. b) Dataset used for the construction of the mixed FFLs catalogue.